The medical practitioners to control the high glycemic peaks in diabetes
after a meal prescribe a-glucosidase inhibitors.
a-glucosidase inhibitors retard the digestion
of carbohydrates to simpler carbohydrates and slows down the absorption
of the later in the small intestine thereby preventing the high glucose
concentration in the blood after a meal.
practitioners have prescribed Salacia reticulata as an oral
antidiabetic agent. The antidiabetic action of S. reticulata
is attributed to the intestinal alpha glucosidase inhibitory activity.
recent research report revealed that Salaretin® (standardized Salacia reticulata Extract from Sami Labs Inc., containing
1% mangiferin) effectively inhibits a-amylase,
the enzyme that catalyze the break down of dietary starch to simple
sugars, there by potentially inhibiting starch digestion. In this
study, the extract was found to inhibit a-amylase
(derived from procine pancreas) in a dose-dependent manner, with 50%
inhibition at a concentration of 30 µg/ml (Fig 1).
1: Inhibitory Effect of SalaretinÒ
on a-amylase Activity
Acarbose, a synthetic drug having an a-glucosidase
inhibitory actiuvity is being used conventionally along with other
hypoglycemic agents in the treatment of diabetes. The a
- glucosidase inhibitory activity of Salaretin® was also
quantitated in a
recent in vitro study.
2: Inhibitory Effect of SalaretinÒ
on a-glucosidase activity
extract was found to inhibit a-glucosidase
from procine jejunum in a dose dependent manner, with 50% inhibition
at a concentration of 7 µg/ml (Fig 2).